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KMID : 0854720120320030144
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 3 p.144 ~ p.149
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Role of Prostaglandin D2 in the Pathogenesis of Asthma
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Choi Jeong-Hee
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Abstract
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Prostaglandin D2 is a major lipid mediator released from activated mast cells of which metabolite 9?,11?-prostaglandin F2 are used as a biomarker of mast cell activation in various type of asthma. Prostagladin D2 acts on DP1 (DP, PTGDR), CRTH2 (DP2) and TP receptors resulting in bronchoconstriction and airway eosinophilia and increase of Th2 cytokines. Several single nucleotide polymorphisms of DP and CRTH2 has been reported to be associated with asthma susceptibility in some population. Thus, prostaglandin D2 may play an important role for the pathogenesis of asthma. Therefore, prostaglandin D2 could be a potential new therapeutic target for asthma. Indeed, several CRTH2 antagonists are currently under investigation for the treatment for asthma. Here, this review will summarize the biosynthesis of prostaglandin D2 and its receptors and focus on the role of prostaglandin D2 in the pathogenesis of asthma including genetic association studies.
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KEYWORD
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Prostaglandin D2, Prostaglandin D2 receptor, Asthma, Genetic association study
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